Epigenetics: general characteristics and implications for oral health
서지윤, 박윤정, 이영아, 황지윤, 이인복, 조병훈, 손호현, 서덕규,
소속 상세정보
서지윤 ( Seo Ji-Yun ) - Seoul National University School of Dentistry Department of Conservative Dentistry
박윤정 ( Park Yoon-Jung ) - Ewha Womans University Department of Nutrition Science and Food Management
이영아 ( Yi Young-Ah ) - Inje University Seoul Paik Hospital Department of Dentistry
황지윤 ( Hwang Ji-Yun ) - Sangmyung University Graduate School of Education
이인복 ( Lee In-Bog ) - Seoul National University School of Dentistry Department of Conservative Dentistry
조병훈 ( Cho Byeong-Hoon ) - Seoul National University School of Dentistry Department of Conservative Dentistry
손호현 ( Son Ho-Hyun ) - Seoul National University School of Dentistry Department of Conservative Dentistry
서덕규 ( Seo Deog-Gyu ) - Seoul National University School of Dentistry Department of Conservative Dentistry
KMID : 1034420150400010014
Abstract
Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.
키워드
Dental pulp cell; Epigenetic mechanism; Epigenetics; Gene regulation; Periodontitis
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